Thirteen years across molecular modelling, clinical machine learning, autonomous-vehicle perception and shipped consumer software — moving between the room where a result has to be defended and the room where it has to be shipped and paid for. Below is the work itself, newest first. Every figure is from a project I did, in a domain I had to learn first.
Singapore-MIT Alliance · 2008–2013 Full fellowship. Inverse design of protease inhibitors.
MSc, Informatics (AI)
University of Edinburgh · 2006–2008
Trained to run the business
MBA
UC San Diego, Rady School · 2016–2018 Merit scholarship. Technology management.
Since then
Co-founder & CTO, fractional CTO, and founder of an independent practice.
The dates overlap on purpose. I took the MBA in the evenings between 2016 and 2018 while working as a Senior Computer Scientist at USC's Alzheimer's Therapeutic Research Institute — leading the team whose platform helped secure a $70M NIH grant. I did not move from research to business. I have been doing both at once since 2016.
DynamWorks LLC · Founder & CEO · 2023–present
Applied-research sprints
Research work for people who hold the domain and not the computational tooling. One engagement took a neuroscience thesis written in Russian in 2005–06 and rebuilt its analysis on current tooling — translation, computation and defence figures, carried across two languages and a technology generation without losing the domain truth.
Event-related potentials · 2026Four questions about one effect, in one figure. Where it sits on the scalp, when it falls in the epoch, how long it holds per electrode, and how large it is. One set of electrode labels runs through all four panels, so a finding can be followed from one to the next. Figure reproduced with the permission of Oksana Shelest.Event-related potentials · topography detailScalp topography at the peak. A signed quantity on a diverging scale with zero pinned at white, electrodes at their 10–20 positions carrying their own values — readable as a field or as a table, whichever the reader needs. Figure reproduced with the permission of Oksana Shelest.
DynamWorks LLC · Founder & CEO · 2023–present
On-device AI products
An independent practice whose products are in the App Store rather than in a slide deck — a Tamil and Tamil Brahmi keyboard, a handwriting-to-font app, a browser computer-vision playground, and an agentic video-analysis framework released open source. Inference runs on the user's machine, which forces every honest engineering tradeoff at once: memory, latency, model size, quality.
3App Store products live
478Facial landmarks tracked in-browser
0Installs needed to run the demos
AGPLVisionUX released open source
DynamWorks · live on the siteReal-time 3D, state sync and a grounded assistant in one page. Choosing an avatar updates two further views — the chat panel header and the corner launcher — each holding its own copy rather than sharing one. The assistant answers only from documents I control: it quotes published prices, books nothing and sees no records.
Things you can open right now
Real-time pose detection, 478-point landmark tracking and edge detection, all processed locally — no install, no server, nothing uploaded. Open it on a laptop with a webcam and it runs in the tab.
Dr. Reem Sharhan Naturopathic Medicine · Fractional COO & CTO · 2024–present
A clinic's software, and its operations
Perirosa — an App Store patient app for perimenopause and HRT tracking that produces twelve-month clinical summary PDFs, built with no account, no cloud and no analytics: a year of a patient's most sensitive data stays on their phone, out of reach of the clinic and of me. Alongside it, an AI phone receptionist that triages callers and answers strictly from per-question scoped sources — it books nothing, reaches no records and gives no medical advice. I also run the practice's bookkeeping, filings and administrative workflows.
Perirosa · iPhoneEntering an HRT regimen, on the device. Dose, route, category and schedule are modelled the way the clinic asks about them, so what a patient records arrives already in the shape a clinician reads. Nothing leaves the phone.
TaxMD · Fractional CTO · 2026
Fractional CTO to a regulated tax platform
Led a twenty-four-person cross-functional team under a single technical vision, consolidating nineteen services and four datastores onto one system of record while the platform stayed live for its users. The engagement has ended; the rest of it stays with them.
Co-founded a venture-backed sensor company and led its technology. The calibration work began in 2020, a year before the company was incorporated: continuous dynamic calibration across LiDAR, radar and camera, running under real-time embedded constraints rather than as an offline batch. Productized as Curium Calibration Edge and launched at CES 2023; covered by a published international patent application. The domain is far from biology — registering one modality onto another is the same problem.
8×Valuation growth in 24 months
15Engineers built across 3 countries
€1MEureka GlobalStars grant secured
CESProduct launched, 2023
Proc. SPIE Future Sensing Technologies · 2020LiDAR returns projected onto the camera frame after calibration. The photograph is held in greyscale so the points carry all the colour, and the test of the method is simply whether they land on the cars.Proc. SPIE Future Sensing Technologies · 2020The same object at three densities. Full point cloud, uniform downsample, learned feature points — on identical axes, so what each reduction throws away is arguable rather than assumed.
Alzheimer's Therapeutic Research Institute, USC · Senior Computer Scientist · 2016–2021
Machine learning into clinical research practice
Led the eight-person team building an AI-powered electronic data capture platform for multi-site clinical research — the platform that helped secure a $70M NIH grant — and deployed a medical-coding model that cut coding time from days to hours. Multi-modal classification from video and audio, and adverse-event classifiers benchmarked against the established method rather than reported in isolation. Four peer-reviewed publications, presented at AAIC in London and Chicago. Patient data; nothing from it belongs on a public page.
$70MNIH grant supported
60%First-year adoption, medical-coding AI
8Engineers and scientists led
days → hoursMedical coding turnaround
The Scripps Research Institute · Research Scientist · 2013–2016
Docking software that is still in use
Built AutoDockFR, a protein–ligand docking engine that handles receptor flexibility — up to fourteen flexible side chains — where most tools assume the receptor holds still, and AutoSite, which finds where a ligand can bind and predicts the shape it would take there. Both ship in the AutoDock Suite and are still cited a decade on, which is the only durability test that counts for research tooling.
AutoDockFR · PLoS Computational Biology, 2015Native interactions recovered — one row per system, one column per flexible side chain. Docked poses reproduced 79.8% of native interactions on average.AutoDockFR · 2015Apo, holo and docked conformations on one mesh. Side chains are drawn twice in contrasting colours, so the reader sees lysine 33 swing out of the pocket to admit the ligand without losing the eleven that did not move.AutoSite · Bioinformatics, 2016Predicted feature points against the measured ligand. Raw point cloud on the left, clustered prediction as translucent spheres on the right; colour carries atom type.
Singapore-MIT Alliance · Doctoral research · 2008–2013
Designing inhibitors that resistance cannot outrun
Computational design of inhibitors for the hepatitis C NS3/NS4A protease, shaped to stay inside the space the natural substrate already occupies — so a mutation that escapes the drug also costs the enzyme its own function. Hierarchical scoring: fast grid energies first, then dead-end elimination and A* to rank candidate functional groups, then expensive accurate energy functions on the survivors.
Doctoral thesis · 2013A designed inhibitor inside the substrate envelope. Surface, ligand and receptor on three layers, with the surroundings held back in a lighter treatment so the eye reads depth instead of clutter.
Moving pictures
Watch it run
A decade apart, both still running. The older is research software that is still cited; the newer runs in your browser while you read this.
AutoDockFR · recorded at Scripps ResearchThe docking software in use. Recorded when the paper was published. The software is still distributed as part of the AutoDock Suite and still cited — which is the only durability test that counts for research tooling.
DynamCV Playground · screen recordingReal-time pose and landmark tracking, in the browser. No install, no server, nothing uploaded — the model runs on the machine watching it.
Continuous Dynamic Calibration for multi-sensor fusion across LiDAR, radar and camera — co-inventor. Published international patent application WO 2022/031226.
patent application
Full record — 9 peer-reviewed publications across computational molecular modelling, clinical machine learning and multi-sensor calibration. Keynote, SAE WCX 2021.
I run DynamWorks, an independent practice taking domain-expert product visions into production — fractional CTO engagements, applied-research sprints, and hands-on delivery for healthcare, research and regulated clients. I take the work where the domain matters as much as the engineering.